About HYDRASHIFT
Therapeutic monoclonal antibody (mAb) inclusion in Multiple Myeloma treatment regimens offer patients significant improvements in clinical outcomes. Daratumumab and isatuximab are human mAb targeting CD38 used in Multiple Myeloma treatment regimens.
HYDRASHIFT removes therapeutic mAb interference on Immunofixation assays to allow for accurate interpretations.
Key benefits
Unique shift technology
HYDRASHIFT daratumumab and HYDRASHIFT isatuximab shift daratumumab and isatuximab interference on HYDRAGEL IF tests.
Trust in the results
HYDRASHIFT reduces the risk of incorrect IF interpretation to improve therapy monitoring.
Easy to implement
Fully integrated into IF protocol without sample pre-treatment for a standardized process compliant to IMWG guidelines.
Follow IMWG guidelines
Process compliant to IMWG guidelines to assess response to treatment in patient with Multiple Myeloma.
Main characteristics
HYDRASHIFT is an immunofixation procedure performed on HYDRAGEL IF 2/4 gel and based on the creation of a mAB/ anti mAB immune complex shifts the mAB drug (daratumumab or isatuximab) into the alpha zone.
This complex is visible in the IgG and kappa immunofixation tracks. A negative HYDRASHIFT result demonstrates the absence of endogenous M-protein.
Serum
Sensitivity
The limit of immune complex visualized is 0.3 g/L.
- HYDRASHIFT 2/4 daratumumab (20 tests) – P/N: 4639
- daratumumab control – P/N: 4765
- HYDRASHIFT 2/4 isatuximab (40 tests) – P/N: 4642
- isatuximab control P/N: 4764
Featured instruments for HYDRASHIFT
See all instruments
Related resources
See all resourcesMultiple Myeloma clinical cases for diagnosis and monitoring according to latest IMWG recommendations
Educational Webinar with Prof. Alessandro Gozzetti, MD, PhD
Scientific publications
See all publicationsHYDRASHIFT avoids monoclonal antibody interference on IMMUNOFIXATION
The HYDRASHIFT portfolio include IVD test to mitigate interferences seen in immunofixation result for patient treated with daratumumab.
Experience and recommendations of a Major Cancer Center to use HYDRASHIFT daratumumab
Immunotherapies for Multiple Myeloma, like the monoclonal antibody daratumumab, can create false positive IgG Kappa bands on Immunofixation gels. This paper describes best practice guidelines for using the Hydrashift assay to remove daratumumab interference from Immunofixation gels.
Interested in HYDRASHIFT?
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