Measurement of serum free light chains (FLC) is an important part of the diagnosis of monoclonal gammopathies.
Together with serum protein electrophoresis and immunofixation/immunotyping, FLC measurement is part of international guidelines, notably for the aid of diagnosis and monitoring of patients with multiple myeloma. FLC testing is also used for the aid of diagnosis and monitoring of patients with AL Amyloidosis.
This workshop recorded during the 25th WorldLab / EuromedLab (2023) focuses on the clinical use of Free Light Chains for Multiple Myeloma and AL Amyloidosis.
Pr. Palladini reviews the different international guidelines and recommendations about FLC testing and reminds the cut-off commutability (« 20 » and « 100 » ratios) between Sebia assay and a predicate method, recently published by Willrich M.A.V et al., in 2022.