Excessive chronic alcohol consumption is a public health problem. Its diagnosis and monitoring will improve clinical outcome, reduce accidents and costs related to alcohol. Carbohydrate Deficient Transferrin (CDT) is the IFCC recommended biomarker for chronic alcohol abuse. CAPI 3 CDT and MINICAP CDT are designed to quantify CDT by capillary electrophoresis on patient serum samples. During analysis, serum transferrin isoforms are separated into five major fractions according to their sialylation level:
- Asialotransferrin (non-sialylated)
CDTIFCC percent value is automatically displayed based on the calibration curve of disialotransferrin.
If CDTIFCC is not implemented, a classic CDT percent value is automatically calculated using the low-sialylated isoforms, i.e., disialotransferrin associated with asialotransferrin (if present).
The interpretation is simple. CDTIFCC greater than 2% are abnormal and indicative of chronic alcohol abuse whereas with classic CDT, results over 1.6%. are abnormal and indicative of chronic alcohol abuse.