Hemoglobin A1c is used clinically as a biomarker for the diagnosis and management of diabetes mellitus. Various methods are available to measure HbA1c and each has advantages and limitations. The focus of this presentation is on the clinical and operational aspects of using capillary electrophoresis as an analytical method for HbA1c measurement. Learning Objectives
List the different analytical methods for measuring HbA1c
Describe the clinical aspects of Capillary electrophoresis for HbA1c analysis
Describe the operational aspects of Capillary electrophoresis for HbA1c analysis
Dr. Grenache is the chief scientific officer for TriCore Reference Laboratories in Albuquerque, New Mexico. In that role, he leads the TriCore Research Institute and works cooperatively to develop and implement TriCore’s scientific research strategy. He is also the medical director of the chemistry, immunology, and esoteric analytic chemistry labs, a clinical professor of pathology at the University of New Mexico, and president of the American Association for Clinical Chemistry. He is a diplomate of the American Board of Clinical Chemistry and a Fellow in the AACC Academy. His research interests are centered on leveraging longitudinal laboratory data to gain insights into population health and the diagnostic tests used to manage the pregnant patient.
HbA1c is routinely used in the clinical laboratory to diagnose and monitor diabetes mellitus. Many methods have been standardized to provide precise and accurate results for normal patients. For the other common Hb variants, most of the methods are now relatively free of analytical interference.