Hemoglobin electrophoresis is a well-established technique routinely used in clinical laboratories to screen patient samples for hemoglobinopathies (hemoglobin variants and thalassemias).
Many international societies including TIF(1), CDC and APHL(2) recognise the benefits of the Sebia Capillary Electrophoresis (CE) technology, such as the high resolution and its clear hemoglobin fractions profile in the screening of hemoglobin disorders.
In addition to Capillary electrophoresis, Sebia provides Gel technique-based solutions: HYDRAGEL HEMOGLOBIN(E) and HYDRAGEL ACID(E) HEMOGLOBIN(E) on the HYDRASYS instruments that enable the separation of the hemoglobins and the detection of the major hemoglobin variants: S or D and C or E, by electrophoresis on alkaline agarose gels.
Electrophoresis on acidic gels, like HYDRAGEL ACID(E) HEMOGLOBIN(E), should follow to confirm the identification of hemoglobin variants, mainly, to differentiate hemoglobins S from D and E from C.
The visualization of the gel provides qualitative and quantitative (HbA and HbA2) analysis.