Serum and Urine
Immunotyping
Fully automated monoclonal proteins identification by Capillarys electrophoresis.
About Serum and Urine Immunotyping
Immunotyping is used to detect and identify monoclonal proteins in serum and urine. Serum and urine proteins are mixed with specific antisera against Gamma- (IgG), Alpha- (IgA), Mu- (IgM) heavy chains Kappa (κ) and Lambda (λ) free and bound light chains.
Immunoglobulins specifically react with their corresponding antiserum and each antiserum pattern (IgG, IgA, IgM, κ and λ) is automatically overlaid with the ELP (Protein Electrophoresis) reference curve. Disappearance of the abnormality in the antiserum-treated pattern indicates the presence of a monoclonal protein.
Key benefits
Fully automated testing
Qualitative analysis with fast separation and good resolution of serum and urine samples.
Direct visualisation of serum and urine protein profile
for quick identification of suspect monoclonal proteins (IgG, IgA, IgM, Kappa (κ) and Lambda (λ)) involved in gammopathy.
High quality of antisera ready to use
for an optimum reaction performance and correct monoclonal component identification.
Scalable solutions
to best fit the need for all sized laboratories, from a standalone instrument to workcell up to a Total Lab Automation (TLA) configuration.
Main characteristics
- Based on the principle of capillary electrophoresis in free solution. Serum or Urine proteins are mixed with specific antisera.
- Immunoglobulins specifically react with their corresponding antiserum. At the end of the analysis, each antiserum pattern (IgG, IgA, IgM, κ and λ) is automatically overlaid with the ELP (Protein Electrophoresis) reference curve.
- Disappearance of the abnormality in the antiserum-treated pattern indicates the presence of a monoclonal protein.
Serum & Urine
- Full traceability and positive sample ID from primary tube samples
- Full traceability and reagents management through RFID tags for both reagents and antisera
- On board antisera vials kept at cool temperature
- Full automation
- Color-coded backlit reagent containers
Sensitivity
- Monoclonal protein can be detected at a concentration as low as 12.5 mg/dL in serum. According to the mobility of the monoclonal component and polyclonal background, the sensitivity may vary.
- Protein abnormality limit of detection is approximately 9 mg/L with CAPI 3 URINE.
Throughput (tests/hour)*
IMMUNOTYPING
CAPILLARYS 3 OCTA (serum or urine) 9
CAPILLARYS 3 TERA (serum or urine) 11
CAPILLARYS 3 TERA MC3 (serum or urine) 27
CAPILLARYS 3 TERA TLA (serum) 13 (front loading only)
MINICAP FLEX-PIERCING (serum) 1.7
* Using Software version 9.30
- CAPI 3 IMMUNOTYPING – P/N: 2600
- MINICAP IMMUNOTYPING – P/N: 2300
Featured instruments for Serum and Urine Immunotyping
See all instrumentsCAPILLARYS 3 OCTA
Evolution makes the difference.
CAPILLARYS 3 TERA MC
Capillary Electrophoresis solution to meet your high capacity needs.
CAPILLARYS 3 TERA TLA
Connect our flexible electrophoresis instrument on lab automation track.
MINICAP FLEX-PIERCING
The compact and affordable automation of Capillary Electrophoresis.
Related resources
See all resourcesApr. 11, 2022 Jul. 15, 2025
IFCC Euromedlab 2021
Sebia booth: #121
Sebia Workshop: EduW22
Performance of Immunotyping vs. Immunofixation for the Detection of Monoclonal Gammopathies
Educational Webinar with Katie Thoren, PhD, Memorial Sloan Kettering Cancer Center
Early detection of Multiple Myeloma: The importance of serum protein electrophoresis
Educational Webinar with Dr. Julien GUILLEMAUD
Jun. 27, 2022 Jun. 29, 2022
IFCC Worldlab 2022
Sebia booth: #72
Sebia Workshop: EduW25
Challenges in Implementing Capillary Electrophoresis for Immunotyping
Educational Webinar with Dr. Jack Maggiore from Loyola University Medical Center in Chicago, IL
May. 22, 2023 May. 24, 2023
IFCC Euromedlab /WorldLab 2023
Sebia booth: #21
Sebia Workshop: EduW15
Apr. 10, 2025 Apr. 12, 2025
European Myeloma Network Meeting – EMN 2025
Sebia booth: #6
CAPILLARYS 3 TERA MC testimonial
Watch the video to hear about the experience from one of our CAPILLARYS 3 TERA MC evolution customer.
Scientific publications
See all publications
Learn more about our unique technologies
Interested in Serum and Urine Immunotyping?
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