Regionally, the median estimated prevalence of MS is greatest in Europe (80 per 100 000), followed by the Eastern Mediterranean (14.9), the Americas (8.3), the Western Pacific (5), South-East Asia (2.8) and Africa (0.3). Regionally, the median estimated incidence of MS is greatest in Europe (3.8 per 100 000), followed by the Eastern Mediterranean (2), the Americas (1.5) and the Western Pacific.
The Multiple Sclerosis is classified into 4 forms:
Many disorders of the central nervous system are associated with increased concentration of Cerebral Spinal Fluid (CSF) proteins either due to increased permeability of blood-CSF barrier or to synthesis of immunoglobulins, primarily IgG, within the central nervous system (CNS).
Presence of intrathecal IgG synthesis suggests inflammatory disease of the CNS, such as caused by multiple sclerosis (MS). Although oligoclonal banding is neither diagnostic nor specific for MS, it is widely used as supportive information and considered an essential test by the European consensus and international guidelines. It is confirmatory in patients with clinical MS episodes and suggestive in patients with only few episodes or inconclusive clinical symptoms.
Among others, the European consensus set criteria for the detection of IgG oligoclonal banding in the CSF. HYDRAGEL 3 & 9 CSF ISOFOCUSING tests meet all the criteria as follows:
2017 Mc Donald Criteria for multiple sclerosis diagnosis includes CSF IgG oligoclonal bands.
2005 Multiple sclerosis consensus criteria includes CSF IgG oligoclonal bands.
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Large menu with high quality results on gel electrophoresis.
The gold standard assay to objectively detect CNS local IgG synthesis in multiple sclerosis.
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