Free Light Chains (FLC)

The next generation Free Light Chain Assay.

About FLC

  • Free Light Chains (FLCs) are immunoglobulin light chains which are circulating in serum in a free state (unbound). There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ).
  • The quantification of serum FLC is used as an aid in the diagnosis and monitoring patients with Multiple Myeloma.
  • Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges may indicate presence of plasma cell disorders disease like Multiple Myeloma or AL amyloidosis in a patient.
  • Nephelometric and turbidimetric based assays have been shown to overestimate the sFLC levels that are not always consistent with Serum Protein Electrophoresis/Immunofixation and other clinical parameters.

Key benefits

Reliable and high analytical performance results

with correct estimation of FLC values without antigen excess or overestimation by polymerization vs Nephelometry / Turbidimetry Methods.

Trust in the results

with concordance value between SPE and FLC Kappa & FLC Lambda which help on interpretation results.

Easy to implement

for patient therapy monitoring and meeting IMWG guidelines.

4 times lower retest rates

vs other methods and lower manual dilutions needed.

Easily adapted and scalable

to any type of ELISA Instrument for standardization and efficiency process.

Clinical performance
96,8% concordance*
Clinical performance
96,8% concordance*

Main characteristics

Test Principle

Quantification of Kappa or Lambda Free Light Chains is performed with an Enzyme-Linked Immunosorbent Assay (ELISA) procedure utilizing specific antibodies anti-Kappa or anti-Lambda free light chains.

Sample Type

Serum sample

Product details

Microplate with 96 wells in strip format.


  • FLC Kappa – P/N: 5102
  • FLC Lambda – P/N: 5103
  • FLC Control Level 1 – P/N: 5112
  • FLC Control Level 2 – P/N: 5113